| Medical Weight Loss Medications: GLP-1s vs. Phentermine & Phendimetrazine

Medical weight loss has evolved significantly, offering patients more effective and personalized options than ever before. At LoCicero Health, we utilize evidence-based medications as part of a comprehensive, physician-supervised program to help patients achieve sustainable weight loss.

Two of the most commonly used medication approaches include:

• GLP-1–based therapies (long-term metabolic support)
• Sympathomimetic medications (short-term appetite suppression)

Understanding how these treatments work — and when they’re appropriate — can help you make informed decisions about your care.

| GLP-1 Medications: A Long-Term Approach to Weight Management

GLP-1 (glucagon-like peptide-1) medications mimic a natural hormone that regulates appetite, digestion, and blood sugar.

Common GLP-1 Medications

• Semaglutide
• Tirzepatide

How GLP-1s Work

GLP-1 medications support weight loss by:

• Reducing appetite and cravings
• Slowing digestion to increase fullness
• Improving blood sugar control
• Helping patients naturally reduce caloric intake

Benefits of GLP-1 Therapy

• Sustainable, gradual weight loss
• Improved metabolic health
• Long-term weight maintenance support

These medications are typically used as part of a long-term weight management strategy.

| Sympathomimetic Medications: Short-Term Support for Weight Loss

Sympathomimetic amines are stimulant-based medications that help reduce appetite and increase energy levels.

Common Options

• Phentermine
• Phendimetrazine

How They Work

These medications:

• Suppress appetite by acting on the central nervous system
• Increase alertness and energy
• Help reduce cravings and portion sizes

Best Use Case

Sympathomimetics are typically used for:

• Short-term weight loss (weeks to a few months)
• Jumpstarting progress and motivation
• Patients needing immediate appetite control

| Who Is a Candidate for Weight Loss Medications?

You may benefit from medical weight loss treatment if you:

• Have a BMI ≥ 30
• Have a BMI ≥ 27 with weight-related conditions
• Have struggled with traditional diet and exercise alone
• Are seeking a medically supervised, non-surgical option

At LoCicero Health, we perform a comprehensive evaluation to determine the safest and most effective approach for you.

| What to Expect from Treatment

Ongoing Monitoring

We closely monitor:

• Weight loss progress
• Vital signs (including blood pressure and heart rate)
• Medication response and side effects

Lifestyle Integration

Medications are most effective when combined with:

• Sustainable dietary changes
• Consistent physical activity
• Long-term habit development

Visit our Weight Management Center